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Question:
I am a kLeinfelter Syndrome man, age 56. I have been on testosterone therapy (2cc/3 weeks, deletestril) for about 25 years. My sex drive seems to be very strong - which fortunatly is NOT a problem for my wife. But I guess I wonder if the continued hight drive is due mostly to the continued level of testosterone therapy, and also what longer-term side effects might result from this therapy.

Answer:
by :
(05/13/2004)
Klinefelter’s Syndrome is a genetic disorder caused by the presence of an extra X chromosome. Individuals with Klinefelter’s syndrome have a sex chromosome patter of XXY rather than the normal XY pattern. It is estimated that it about 0.2% of all live-born males are born with this abnormal chromosome pattern.

Males with Klinefelter’s syndrome have rudimentary testes and prostate glands. Starting during puberty the testes normally produce testosterone which is required for initiating and maintaining a males secondary sex characteristics and sex drive. Since the testes are under developed in males with Klinefelter’s syndrome they produce below normal levels of testosterone.

Periodic supplemental injections of testosterone is a standard medical treatment for men with Klinefelter’s. Syndrome. Testosterone treatment is normally well tolerated and is not associated with any serious health risks. Since testosterone is steroid hormone it has a long half-life in the body, which explains why it only needs to be injected every two to three weeks.

If the testosterone treatments are halted there may vary well be a reduction in sex drive as well as a deterioration in the presence of secondary sex characteristics such as body and facial. However, this reduction in both the sex drive and secondary sex characteristics will occur gradually due to the chemical nature of testosterone and its long half-life.

Reviewed by Sexual Health Editorial Team

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